Link Pointed Between Gum Disease Bacteria and Alzheimer's

Link Pointed Between Gum Disease Bacteria and Alzheimer’s

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New research published in the scientific journal ‘Frontiers in Aging Neuroscience’ by scientists from Tufts University (United States) has found a relationship between the bacterium ‘Fusobacterium nucleatum’ (‘F. nucleatum’) and Alzheimer’s disease. The ´F. nucleatum’ is a type of common bacteria that proliferates in the disease …


New research published in the scientific journal ‘Frontiers in Aging Neuroscience’ by scientists from Tufts University (United States) has found a relationship between the bacterium ‘Fusobacterium nucleatum’ (‘F. nucleatum’) and Alzheimer’s disease.

The ´F. nucleatum’ is a common type of bacteria that proliferates in periodontal disease. It affects the gums and jaw bone and, if left untreated, leads to tooth instability and loss. In recent years, ´F. nucleatum’ has been linked to conditions ranging from colorectal cancer to premature delivery of babies.

In this study, our laboratory is the first to discover that Fusobacterium nucleatum can generate systemic inflammation and even infiltrate the tissues of the nervous system and exacerbate the signs and symptoms of Alzheimer’s disease“, it states Jake Jinkun Chen, labor leader.

F. nucleatum’ can also cause severe generalized inflammation, which is a symptom of many chronic diseases, such as type 2 diabetes and Alzheimer’s disease.

Chen and his colleagues believe that by attacking the ‘F. nucleatum’ can slow the spread and progression of at least two epidemics: periodontal disease, which affects 47 percent of American adults over the age of 30, and Alzheimer’s, which affects 6.5 million Americans today. and is expected to increase to more than 14 million by 2060.

The latest research, carried out in mice, shows that ´F. nucleatum’ causes an abnormal proliferation of microglial cells, which are immune cells in the brain that normally clear damaged neurons and infections and help maintain the overall health of the central nervous system.

The researchers found that this excess of microglial cells also created a heightened inflammatory response.. Chronic inflammation or infection is thought to be a determining factor in the cognitive decline that occurs as Alzheimer’s progresses.

Our studies show that ´F. nucleatum’ can reduce memory and thinking abilities in mice through certain signaling pathways. This is a red flag for researchers and doctors alike.Chen says.

In the past, scientists have raised possible links between periodontal disease and Alzheimer’s. Although the new research does not show that periodontal disease related to ‘F. nucleatum’ leads directly to Alzheimer’s disease, the new study suggests that periodontal disease caused by ‘F. nucleatum’ and left untreated or poorly treated could exacerbate the symptoms of Alzheimer’s disease. Conversely, effective treatment of periodontal disease in those with early-stage Alzheimer’s could slow the progression of Alzheimer’s.

Tests of bacterial load and degree of symptoms may one day become a way to measure the effects of ‘F. nucleatum’ and manage treatment to stop the progression of both periodontal disease and Alzheimer’sChen details.

Their research also suggests possible pharmacological targets that could specifically quench the local and systemic inflammation caused by ´F. nucleatum’ in a periodontal environment.

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